You can now view the reference list for our piece on ERAS.
See below to listen, and visit the Episode Library to access them and check out all other episodes.
Episode #12 of the How We Treat CRC Podcast is now available.
Drs. Bleday and Meyerhardt speak with Dr. Kevin Elias about "Enhanced Recovery After Surgery" methods and studies taking place right now in reducing stress on the patient's body pre-surgery. Even eating, hydrating, and carbohydrates are involved in prepping for common surgeries CRC doctors will want to learn more about.
Click here to read Kevin's full bio.
To view this episode's references and more information on the studies mentioned in this episode, visit the How We Treat CRC Podcast's episode library on this blog.
Click here to listen on iTunes.
Episode 11 is now available on SoundCloud and iTunes.
Second, the podcast is joined by Dr. Rodrigo O. Perez from Brazil who worked on the Watch and Wait approach with Dr. Angelita Habr-Gama. He is an expert on the topic, and shares some of his experiences working with one of the innovators in colorectal cancer treatment.
According to their team's study and paper in Dis Colon Rectum in 2013, "No immediate surgery (Watch and Wait) has been considered in select patients with complete clinical response after neoadjuvant chemoradiation to avoid postoperative morbidity and functional disorders after radical surgery."
Below are some references to the topics discussed in this month's episode. Enjoy!
Brazilian protocol, originally proposed by Habr-Gama in 2006:
(Habr-Gama et al., 2010) – follow-up study looking at short term data
(Habr-Gama et al., 2013) – same group, looking at longer-term outcomes
MSKCC protocol (Smith et al., 2012)
van der Valk’s presentation at ASCO in 2017 re: update from the International Watch & Wait database
A recent retrospective study in Dis Colon Rectum that appeared in March 2017 (from Kong and others in Australia) that tracked outcomes with those patients end up needing a salvage operation following “watch and wait”
A recent review by Habr-Gama and others:
Two good review/perspective piece on the topic of watch and wait in this disease:
Torok et al., 2016
Glynne-Jones and Hughes, 2016
Episode #9 focuses on Heated Intraperitoneal Chemotherapy (HIPEC) treatment. For those that may be unfamiliar with the topic, HIPEC is a highly concentrated and heated type of chemo directed at the abdomen during surgery. HIPEC differs from more traditional and systemic treatments due to the delivery of drugs into a patient's body. The chemo does not circulate through the entire body during HIPEC. It only delivers directly to the cancerous cells.
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In the second part of our discussion on colorectal cancer trials, Dr. James Fleshman joins Ron to discuss the ACOSOG Z6051 Randomized Clinical Trial. This surgical trial aims to decipher the differences of open versus laparoscopic surgery in the treatment of colorectal cancer. To read more about Dr. Fleshman's findings and reports click here.
Dr. Fleshman is the Helen and Stanley Joseph Seeger Professor and Chairman, Department of Surgery at Baylor University Medical Center in Dallas. His professional focus is the treatment of patients with colorectal diseases. He has developed an international reputation in the laparoscopic treatment of colorectal cancer and the development of randomized controlled trials to evaluate the use of laparoscopic techniques in the treatment of colorectal cancer. Click here to read a full bio.
In this episode, Jeff and Ron also answer a listener question and discuss the future of patient trials in this field.
The How We Treat Colon & Rectal Cancer podcast's next two episodes will feature discussions about clinical trials focused on colorectal cancer treatment. In part one, Dr. Deborah Schrag joins us to provide an inside look at the PROSPECT trial currently taking place.
PROSPECT is the acronym for Preoperative Radiation Or Selective Preoperative Radiation and Evaluation before Chemotherapy and Total Mesorectal Excision (TME). From the on-going trial, Dr. Schrag and her team hope to decipher and compare the results of standard chemo and radiation treatment using a regimen of drugs named FOLFOX (the drugs 5-fluorouracil (5-FU), oxaliplatin and leucovorin). To learn more about this trial, listeners can click here.