Episode 11: Watch and Wait Protocol

Episode 11 is now available on SoundCloud and iTunes. 

First, the team analyzes a case involving rectal cancer in a 65 year old male patient at a team conference. Guests featured in the segment are Dr. Jeff Wisch and Dr. Harvey Mamon

Second, the podcast is joined by Dr. Rodrigo O. Perez from Brazil who worked on the Watch and Wait approach with Dr. Angelita Habr-Gama. He is an expert on the topic, and shares some of his experiences working with one of the innovators in colorectal cancer treatment. 

According to their team's study and paper in Dis Colon Rectum in 2013, "No immediate surgery (Watch and Wait) has been considered in select patients with complete clinical response after neoadjuvant chemoradiation to avoid postoperative morbidity and functional disorders after radical surgery." 

Below are some references to the topics discussed in this month's episode. Enjoy!

Brazilian protocol, originally proposed by Habr-Gama in 2006:



(Habr-Gama et al., 2010) – follow-up study looking at short term data



(Habr-Gama et al., 2013) – same group, looking at longer-term outcomes



MSKCC protocol (Smith et al., 2012)



van der Valk’s presentation at ASCO in 2017 re: update from the International Watch & Wait database



A recent retrospective study in Dis Colon Rectum that appeared in March 2017 (from Kong and others in Australia) that tracked outcomes with those patients end up needing a salvage operation following “watch and wait”




A recent review by Habr-Gama and others:



Two good review/perspective piece on the topic of watch and wait in this disease:

Torok et al., 2016



Glynne-Jones and Hughes, 2016